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Cardiac performance in thyrotoxicosis: Analysis of 10 untreated patients
Journal article   Peer reviewed

Cardiac performance in thyrotoxicosis: Analysis of 10 untreated patients

Abdulmassih S. Iskandrian, Leslie Rose, A-Hamid Hakki, Bernard L. Segal, Sally A. Kane and Lauren K Rose
The American journal of cardiology, v 51(2), pp 349-352
1983
DOI: https://doi.org/10.1016/S0002-9149(83)80064-2
PMID: 6218743
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

This study attempts to define cardiac performance at rest and during exercise in patients with untreated thyrotoxicosis. We studied 7 women and 3 men, aged 23 to 59 years (40 ± 10, mean ± standard deviation [SD]) and compared the results with those obtained in 12 normal subjects. In patients with thyrotoxicosis, the rhythm was sinus and the only untoward symptom was palpitations; the resting electrocardiographic results were normal in 8 patients and showed left ventricular hypertrophy in 2 patients; the left ventricular ejection fraction and volumes (measured by radionuclide ventriculography) were normal at rest. During exercise, 1 patient had dyspnea and 7 had leg fatigue; 2 were asymptomatic. Also, 7 patients had ≥5% increase in left ventricular ejection fraction, 2 had no change, and 1 had a decrease. In all 10 patients, the exercise ejection fraction was ≥60%. All normal subjects had a ≥5% increase in ejection fraction during exercise. There were no significant differences at rest between patients with thyrotoxicosis and normal subjects in blood pressure, ejection fraction, end-diastolic volume, stroke volume, end-systolic volume, or cardiac output, but the heart rate was significantly higher in patients with thyrotoxicosis (91 ± 10 versus 80 ± 12 beats/min, p <0.05). During exercise, there were no significant differences between patients with thyrotoxicosis and normal subjects in blood pressure, end-diastolic volume, stroke volume, end-systolic volume, or cardiac output. The exercise ejection fraction was significantly lower in patients with thyrotoxicosis than in normal subjects (68 ± 10% versus 75 ± 4%, p <0.05). Cardiac performance is normal at rest in patients with thyrotoxicosis, but during exercise abnormal left ventricular reserve occurs in some patients.

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Web of Science research areas
Cardiac & Cardiovascular Systems
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