Journal article
Cardiolipin mediates curcumin interactions with mitochondrial membranes
Biochimica et biophysica acta. Biomembranes, v 1861(1), pp 75-82
Jan 2019
PMID: 30389425
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Curcumin, the main molecular ingredient of the turmeric spice, has been reported to exhibit therapeutic properties for varied diseases and pathological conditions. While curcumin appears to trigger multiple signaling pathways, the precise mechanisms accounting for its therapeutic activity have not been deciphered. Here we show that curcumin exhibits significant interactions with cardiolipin (CL), a lipid exclusively residing in the mitochondrial membrane. Specifically, we found that curcumin affected the structures and dynamics of CL-containing biomimetic and biological mitochondrial membranes. Application of several biophysical techniques reveals the CL-promoted association and internalization of curcumin into lipid bilayers. In parallel, curcumin association with CL containing bilayers increased their fluidity and reduced lipid ordering. These findings suggest that membrane modifications mediated by CL interactions may play a role in the therapeutic functions of curcumin, and that the inner mitochondrial membrane in general might constitute a potential drug target.
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Details
- Title
- Cardiolipin mediates curcumin interactions with mitochondrial membranes
- Creators
- Shani Ben-Zichri - Ben-Gurion University of the NegevSofiya Kolusheva - Ben-Gurion University of the NegevMichael Danilenko - Ben-Gurion University of the NegevSaniya Ossikbayeva - Drexel UniversityWilliam J. Stabbert - Drexel UniversityJuan L. Poggio - Drexel UniversityDavid E. Stein - Drexel UniversityZulfiya Orynbayeva - Drexel UniversityRaz Jelinek - Ben-Gurion University of the Negev
- Publication Details
- Biochimica et biophysica acta. Biomembranes, v 1861(1), pp 75-82
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000451494500009
- Scopus ID
- 2-s2.0-85056238453
- Other Identifier
- 991019168168004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics