Journal article
Cardioprotective effect of genetic ablation of the G-protein-coupled receptor kinase GRK2 in adult pancreatic β-cells during high-fat diet
The Journal of biological chemistry, v 301(4), 108388
01 Apr 2025
PMID: 40054692
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cardiovascular diseases are a major comorbidity factor in patients with type 2 diabetes and a leading cause of death among them. Yet, mechanistically, how impairment in pancreatic islets alters cardiac function under different metabolic states remains largely unknown. Here, we investigate the role of the G-protein-coupled receptor kinase 2 (GRK2) in regulating islet adaptations to an obesogenic diet and its impact on myocardial function. Using a novel inducible β-cell-specific GRK2 knockout mouse model (βGRK2KO), we establish that loss of adult β-cell GRK2 delays metabolic islet maladaptation, protecting the heart against obesity-induced cardiac dysfunction. βGRK2KO are more insulin-sensitive than control mice and have improved cardiac function and myocardial morphology. Thus, genetic ablation of GRK2 in adult β-cells during an obesogenic diet play a cardioprotective role. This study prompts a novel therapeutic window for GRK2 intervention strategies for diabetic patients prone to cardiac dysfunction.
Metrics
1 Record Views
Details
- Title
- Cardioprotective effect of genetic ablation of the G-protein-coupled receptor kinase GRK2 in adult pancreatic β-cells during high-fat diet
- Creators
- Jonathan Snyder - Drexel UniversityChun-sun Jiang - University of Alabama at BirminghamRan Hee Choi - University of UtahTaylor Morgan - Drexel UniversityJeffrey Roman - University of PennsylvaniaLilly Underwood - University of Alabama at BirminghamAnna Maria Lucchese - Drexel UniversitySarah Montgomery - Drexel UniversityLaurel A. Grisanti - University of MissouriNicolai Doliba - University of PennsylvaniaWilliam L. Holland - University of UtahPriscila Y. Sato - University of Alabama at Birmingham
- Publication Details
- The Journal of biological chemistry, v 301(4), 108388
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001471697100001
- Scopus ID
- 2-s2.0-105002415997
- Other Identifier
- 991022197431304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology