Journal article
Cardiovascular disease biomarkers across autoimmune diseases
Clinical immunology (Orlando, Fla.), v 161(1), pp 59-63
01 Nov 2015
PMID: 26168705
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cardiovascular disease is increasingly recognized as a major cause of premature mortality among those with autoimmune disorders. There is an urgent need to identify those patients with autoimmune disease who are at risk for CVD so as to optimize therapeutic intervention and ultimately prevention. Accurate identification, monitoring and stratification of such patients will depend upon a panel of biomarkers of cardiovascular disease. This review will discuss some of the most recent biomarkers of cardiovascular diseases in autoimmune disease, including lipid oxidation, imaging biomarkers to characterize coronary calcium, plaque, and intima media thickness, biomarkers of inflammation and activated complement, genetic markers, endothelial biomarkers, and antiphospholipid antibodies. Clinical implementation of these biomarkers will not only enhance patient care but also likely accelerate the pharmaceutical pipeline for targeted intervention to reduce or eliminate cardiovascular disease in the setting of autoimmunity. (C) 2015 Elsevier Inc. All rights reserved.
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Details
- Title
- Cardiovascular disease biomarkers across autoimmune diseases
- Creators
- Joseph Ahearn - Allegheny Health NetworkKelly J. Shields - Allegheny Health NetworkChau-Ching Liu - College Station Medical CenterSusan Manzi - Allegheny Health Network
- Publication Details
- Clinical immunology (Orlando, Fla.), v 161(1), pp 59-63
- Publisher
- Elsevier
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000364354600009
- Scopus ID
- 2-s2.0-84949529808
- Other Identifier
- 991021933901804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology