Files and links (1)
Published, Version of Record (VoR)CC BY-NC-SA V4.0, Open
Journal article
Cardiovascular dysfunction following spinal cord injury
Neural regeneration research, v 11(2), pp 189-194
Feb 2016
PMID: 27073353
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Both sensorimotor and autonomic dysfunctions often occur after spinal cord injury (SCI). Particularly, a high thoracic or cervical SCI interrupts supraspinal vasomotor pathways and results in disordered hemodynamics due to deregulated sympathetic outflow. As a result of the reduced sympathetic activity, patients with SCI may experience hypotension, cardiac dysrhythmias, and hypothermia post-injury. In the chronic phase, changes within the CNS and blood vessels lead to orthostatic hypotension and life-threatening autonomic dysreflexia (AD). AD is characterized by an episodic, massive sympathetic discharge that causes severe hypertension associated with bradycardia. The syndrome is often triggered by unpleasant visceral or sensory stimuli below the injury level. Currently the only treatments are palliative - once a stimulus elicits AD, pharmacological vasodilators are administered to help reduce the spike in arterial blood pressure. However, a more effective means would be to mitigate AD development by attenuating contributing mechanisms, such as the reorganization of intraspinal circuits below the level of injury. A better understanding of the neuropathophysiology underlying cardiovascular dysfunction after SCI is essential to better develop novel therapeutic approaches to restore hemodynamic performance.
Metrics
Details
- Title
- Cardiovascular dysfunction following spinal cord injury
- Creators
- Elizabeth Partida - Drexel UniversityEugene Mironets - Drexel UniversityShaoping Hou - Drexel UniversityVeronica J Tom - Drexel University
- Publication Details
- Neural regeneration research, v 11(2), pp 189-194
- Grant note
- R01 NS085426 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000373221900001
- Scopus ID
- 2-s2.0-84962523218
- Other Identifier
- 991019167938704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Neurosciences