Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma
Occupational and environmental medicine (London, England), v 75(6), pp 415-420
Jun 2018
PMID: 29588333
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectivesAlthough many studies have investigated the association between trichloroethylene (TCE) exposure and non-Hodgkin’s lymphoma (NHL), less is known about other chlorinated solvents. We extended our previous analysis of occupational TCE exposure in a multicentre population-based case-control study of NHL to investigate associations with five additional chlorinated solvents: 1,1,1,-trichloroethane, carbon tetrachloride, chloroform, methylene chloride and perchloroethylene.MethodsCases (n=1189) and controls (n=982) provided detailed information on their occupational histories and workplace exposure to chlorinated solvents for selected occupations using job-specific interview modules. An industrial hygienist used this information and a review of the literature to assess occupational exposure to chlorinated solvents. We computed ORs and 95% CIs for different exposure metrics, with the unexposed group as the referent. We also computed ORs by NHL subtype.ResultsHigh cumulative hours exposed to carbon tetrachloride was associated with NHL (>520 hours: OR 1.9; 95% CI 1.0 to 3.6; Ptrend=0.04). This association remained after restricting to jobs with high-intensity exposure (OR 2.0; 95% CI 1.1 to 3.8; P=0.03) and ≥90% exposure probability (OR 2.1; 95% CI 1.0 to 4.3; P=0.03), adjusting for TCE (OR 2.1; 95% CI 1.0– to 4.1; P=0.04) and incorporating a 15-year lag (OR 1.9; 95% CI 1.0 to 3.6; P=0.06). The other evaluated chlorinated solvents were not associated with NHL.ConclusionsThis is the first study using high-quality quantitative exposure assessment methods to identify a statistically significant elevated association between occupational exposure to carbon tetrachloride and NHL. Our findings, although limited by a small number of exposed cases, offer evidence that carbon tetrachloride may be a lymphomagen.
Metrics
Details
- Title
- Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma
- Creators
- Catherine L Callahan - National Cancer InstitutePatricia A Stewart - Stewart Exposure Assessments, LLCMelissa C Friesen - National Cancer InstituteSarah Locke - National Cancer InstituteAnneclaire J De Roos - Drexel UniversityJames R Cerhan - Mayo ClinicRichard K Severson - Wayne State UniversityNathaniel Rothman - National Cancer InstituteMark P Purdue - National Cancer Institute
- Publication Details
- Occupational and environmental medicine (London, England), v 75(6), pp 415-420
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000433243000005
- Scopus ID
- 2-s2.0-85061652817
- Other Identifier
- 991019168798604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health