Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Case series review of neuroradiologic changes associated with immune checkpoint inhibitor therapy
Neuro-oncology practice, v 8(3)
01 Jun 2021
PMID: 34055372
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
While Immuno-oncotherapy (10) ha significantly improved outcomes in the treatment of systemic cancers, various neurological complications have accompanied these therapies.Treatment with immune checkpoint inhibitors (ICIs) risks multi-organ autoimmune inflammatory responses with gastrointestinal, dermatologic, and endocrine complications being the most common types of complications. Despite some evidence that these therapies are effective o treat central nervous system (CNS) tumors, there are a significant range of related neurological side effects due o ICIs. Neuroradiologjc changes associated with ICIs are commonly misdiagnosed as progression and might limit treatment or otherwise impact patient care. Here, we provide a radiologic case series review restricted to neurological complications attributed to ICIs, anti-CTLA-4, and PD-L-1/PD-1 inhibitors. We report the first case series dedicated to the review of CNS/PNS radiologic changes secondary to ICI therapy in cancer patients. We provide a brief cas e synopsis with neuroimaging followed by an annotated review of the literature relevant to each case. We present series of neuroradiological findings including nonspecific parenchymal and encephalitic, hypophyseal, neural (cranial and peripheral), meningeal, cavity-associated, and cranial osseous changes seen in association with the u se of ICIs. Misdiagnosis of radiologic abnormalities secondary to neurological immune-related adverse events can imp act patient treatment regimens and clinical outcomes. Rapid recognition of various neuroradiologic changes associated wit h ICI therapy can improve patient tolerance and adherence to cancer therapies.
Metrics
Details
- Title
- Case series review of neuroradiologic changes associated with immune checkpoint inhibitor therapy
- Creators
- Na Tosha N. Gatson - Geisinger Medical CenterMina Makary - Geisinger Medical CenterShane P. Bross - Geisinger Neuroscience InstituteJoseph Vadakara - Geisinger Medical CenterTristan Maiers - Geisinger Medical CenterGino J. Mongelluzzo - Geisinger Medical CenterErika N. Leese - Geisinger Neuroscience InstituteCameron Brimley - Geisinger Medical CenterEkokobe Fonkem - Barrow Neurological InstituteAnand Mahadevan - Geisinger Medical CenterAtom Sarkar - Drexel UniversityRajiv Panikkar - Geisinger Medical Center
- Publication Details
- Neuro-oncology practice, v 8(3)
- Publisher
- Oxford Univ Press
- Number of pages
- 12
- Grant note
- Geisinger Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000661408200004
- Scopus ID
- 2-s2.0-85107956471
- Other Identifier
- 991019168748504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Oncology