Journal article
Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors
Neuron (Cambridge, Mass.), v 67(6), pp 984-996
23 Sep 2010
PMID: 20869595
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
NMDA receptors (NMDARs) play a central role in development, synaptic plasticity and neurological disease. NMDAR subunit composition defines their biophysical properties and downstream signaling. Casein kinase 2 (CK2) phosphorylates the NR2B subunit within its PDZ-binding domain; however, the consequences for NMDAR localization and function are unclear. Here we show that CK2 phosphorylation of NR2B regulates synaptic NR2B and NR2A in response to activity. We find that CK2 phosphorylates NR2B, but not NR2A, to drive NR2B-endocytosis and remove NR2B from synapses resulting in an increase in synaptic NR2A expression. During development there is an activity-dependent switch from NR2B to NR2A at cortical synapses. We observe an increase in CK2 expression and NR2B phosphorylation over this same critical period, and show that the acute activity-dependent switch in NR2 subunit composition at developing hippocampal synapses requires CK2 activity. Thus CK2 plays a central role in determining the NR2 subunit content of synaptic NMDARs.
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Details
- Title
- Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors
- Creators
- Antonio Sanz-Clemente - National Institute of Neurological Disorders and StrokeJose A. Matta - National Institute of Neurological Disorders and StrokeJohn T.R. Isaac - National Institute of Neurological Disorders and StrokeKatherine W. Roche - National Institute of Neurological Disorders and Stroke
- Publication Details
- Neuron (Cambridge, Mass.), v 67(6), pp 984-996
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000282801100010
- Scopus ID
- 2-s2.0-77956998216
- Other Identifier
- 991020099918704721
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- Web of Science research areas
- Neurosciences