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Journal article
Cat carotid body chemosensory discharge (in vitro) is insensitive to charybdotoxin
Brain research, v 747(2), pp 324-327
1997
PMID: 9046009
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Abstract
Charybdotoxin (ChTX), a venom protein, suppresses Ca
2+-activated K
+ (K
Ca
+) currents in the glomus cell of neonatal rat carotid body. If it works similarly for cat carotid body chemoreceptors, charybdotoxin is expected to stimulate the chemosensory discharge during normoxia, and particularly hypoxia and hypercapnia. We studied the effects of charybdotoxin (20–40 nM) in vitro (perfused/superfused) on the cat carotid chemosensory discharge, and simultaneously tissue PO
2 (PtiO
2), as a measure of positive control. ChTX (20 nM) only increased PtiO
2 and decreased carotid chemosensory discharge during hypoxia, indicating vasodilation. We conclude that K
Ca
+ channels do not appear to play a significant role in chemotransduction in the cat carotid body.
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Details
- Title
- Cat carotid body chemosensory discharge (in vitro) is insensitive to charybdotoxin
- Creators
- Shinobu Osanai - University of PennsylvaniaDonald G. Buerk - University of PennsylvaniaAnil Mokashi - University of PennsylvaniaDeepak K. Chugh - University of PennsylvaniaSukhamay Lahiri - University of Pennsylvania
- Publication Details
- Brain research, v 747(2), pp 324-327
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1997WJ06900018
- Scopus ID
- 2-s2.0-0031040002
- Other Identifier
- 991019231726104721
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- Web of Science research areas
- Neurosciences