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Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation
Journal article   Open access   Peer reviewed

Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation

Suravi Chakrabarty, Shruti Choudhary, Arpit Doshi, Fa-Qiang Liu, Rishabh Mohan, Manasa P. Ravindra, Dhruv Shah, Xun Yang and Fraser F. Fleming
Advanced synthesis & catalysis, v 356(10), pp 2135-2196
07 Jul 2014
PMID: 25484847
url
https://doi.org/10.1002/adsc.201400017View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open

Abstract

Chemistry Chemistry, Applied Chemistry, Organic Physical Sciences Science & Technology
Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with metal and non-metal catalysts provides rapid access to a large array of complex nitrogenous structures ideally functionalized for medicinal applications. Isonitrile insertion into transition metal complexes has featured in numerous synthetic and mechanistic studies, leading to rapid deployment of isonitriles in numerous catalytic processes, including multicomponent reactions (MCR). Covering the literature from 1990-2014, the present review collates reaction types to highlight reactivity trends and allow catalyst comparison.

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Chemistry, Applied
Chemistry, Organic
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