Journal article
Catastrophic antiphospholipid syndrome and heparin-induced thrombocytopenia-related diseases or chance association?
Blood coagulation & fibrinolysis, v 26(2)
Mar 2015
PMID: 25304013
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antiphospholipid syndrome (APS) and heparin-induced thrombocytopenia (HIT) are thrombotic disorders due to specific autoimmune-mediated antibodies. Catastrophic APS (CAPS), also known as Asherman's syndrome, is a life-threatening severe form of APS. Diagnostic criteria for CAPS include the development of a thrombotic event of three or more organs in less than a week with the presence of antiphospholipid antibodies and microvascular thrombosis on histology. Thrombocytopenia is seen in more than 60% of cases of CAPS. HIT is a life-threatening disorder with the clinical presentation of thrombocytopenia and arterial or venous thrombosis in patients who develop antibodies to heparin and platelet factor 4 typically within 10 days after starting heparin treatment. Due to the multiple similarities in clinical features and pathophysiology of CAPS and HIT, it has been postulated that these two antibody-mediated disorders may be related. We report two cases in which patients diagnosed with CAPS developed HIT very soon during the same admission as well as a case of a patient initially diagnosed with HIT who presented with CAPS years later.
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Details
- Title
- Catastrophic antiphospholipid syndrome and heparin-induced thrombocytopenia-related diseases or chance association?
- Creators
- Nay T Tun - Drexel UniversityMahesh KrishnamurthyRichard Snyder
- Publication Details
- Blood coagulation & fibrinolysis, v 26(2)
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:000349007300016
- Scopus ID
- 2-s2.0-84922395988
- Other Identifier
- 991019168172504721
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- Web of Science research areas
- Hematology