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Catecholamines restore myocardial contractility in dilated cardiomyopathy at the expense of increased coronary blood flow and myocardial oxygen consumption (MvO2 cost of catecholamines in heart failure)
Journal article   Open access   Peer reviewed

Catecholamines restore myocardial contractility in dilated cardiomyopathy at the expense of increased coronary blood flow and myocardial oxygen consumption (MvO2 cost of catecholamines in heart failure)

Lazaros A. Nikolaidis, Dennis Trumble, Teresa Hentosz, Aaron Doverspike, Rhonda Huerbin, Michael A. Mathier, You‐Tang Shen and Richard P. Shannon
European journal of heart failure, v 6(4), pp 409-419
Jun 2004
DOI: https://doi.org/10.1016/j.ejheart.2003.09.013
PMID: 15182765
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1016/j.ejheart.2003.09.013View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Catecholamines Heart failure Myocardial efficiency Myocardial oxygen consumption
To investigate the metabolic cost of catecholamine use in heart failure, we administered intravenous dobutamine or norepinephrine to dogs with moderate and severe LV dysfunction until LV contractile function was restored to normal levels. Both drugs were associated with significant increases in myocardial O2 consumption, increased coronary blood flow requirements and decreased myocardial mechanical efficiency. These mechanisms may contribute to the deleterious effects of catecholamines in heart failure.

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17 citations in Web of Science
16 citations in Scopus

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Collaboration types
Industry collaboration
Domestic collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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