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Cbx3/HP1 gamma deficiency confers enhanced tumor-killing capacity on CD8(+) T cells
Journal article   Open access   Peer reviewed

Cbx3/HP1 gamma deficiency confers enhanced tumor-killing capacity on CD8(+) T cells

Michael Sun, Ngoc Ha, Duc-Hung Pham, Megan Frederick, Bandana Sharma, Chie Naruse, Masahide Asano, Matthew E. Pipkin, Rani E. George and To-Ha Thai
Scientific reports, v 7(1), pp 42888-42888
21 Feb 2017
PMID: 28220815
url
https://doi.org/10.1038/srep42888View
Published, Version of Record (VoR)CC BY V4.0 Open

Abstract

Multidisciplinary Sciences Science & Technology Science & Technology - Other Topics
Cbx3/HP1 gamma is a histone reader whose function in the immune system is not completely understood. Here, we demonstrate that in CD8(+) T cells, Cbx3/HP1. insufficiency leads to chromatin remodeling accompanied by enhanced Prf1, Gzmb and Ifng expression. In tumors obtained from Cbx3/HP1 gamma-insufficient mice or wild type mice treated with Cbx3/HP1 gamma-insufficient CD8(+) T cells, there is an increase of CD8(+) effector T cells expressing the stimulatory receptor Klrk1/NKG2D, a decrease in CD4(+) CD25(+) FOXP3(+) regulatory T cells (Treg cells) as well as CD25(+) CD4(+) T cells expressing the inhibitory receptor CTLA4. Together these changes in the tumor immune environment may have mitigated tumor burden in Cbx3/HP1 gamma-insufficient mice or wild type mice treated with Cbx3/HP1 gamma-insufficient CD8(+) T cells. These findings suggest that targeting Cbx3/HP1. can represent a rational therapeutic approach to control growth of solid tumors.

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