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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Cbx3/HP1 gamma deficiency confers enhanced tumor-killing capacity on CD8(+) T cells
Scientific reports, Vol.7(1), pp.42888-42888
21 Feb 2017
PMCID: PMC5318867
PMID: 28220815
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cbx3/HP1 gamma is a histone reader whose function in the immune system is not completely understood. Here, we demonstrate that in CD8(+) T cells, Cbx3/HP1. insufficiency leads to chromatin remodeling accompanied by enhanced Prf1, Gzmb and Ifng expression. In tumors obtained from Cbx3/HP1 gamma-insufficient mice or wild type mice treated with Cbx3/HP1 gamma-insufficient CD8(+) T cells, there is an increase of CD8(+) effector T cells expressing the stimulatory receptor Klrk1/NKG2D, a decrease in CD4(+) CD25(+) FOXP3(+) regulatory T cells (Treg cells) as well as CD25(+) CD4(+) T cells expressing the inhibitory receptor CTLA4. Together these changes in the tumor immune environment may have mitigated tumor burden in Cbx3/HP1 gamma-insufficient mice or wild type mice treated with Cbx3/HP1 gamma-insufficient CD8(+) T cells. These findings suggest that targeting Cbx3/HP1. can represent a rational therapeutic approach to control growth of solid tumors.
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Details
- Title
- Cbx3/HP1 gamma deficiency confers enhanced tumor-killing capacity on CD8(+) T cells
- Creators
- Michael Sun - Beth Israel Deaconess Medical CenterNgoc Ha - Drexel UniversityDuc-Hung Pham - Beth Israel Deaconess Medical CenterMegan Frederick - Scripps Research InstituteBandana Sharma - Dana-Farber Cancer InstituteChie Naruse - Kyoto UniversityMasahide Asano - Kyoto UniversityMatthew E. Pipkin - Scripps Research InstituteRani E. George - Harvard UniversityTo-Ha Thai - Beth Israel Deaconess Medical Center
- Publication Details
- Scientific reports, Vol.7(1), pp.42888-42888
- Publisher
- Springer Nature
- Number of pages
- 12
- Grant note
- R21CA198263 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Friends for Life Research Grant AI099012 / NIH-NIAID grant Mayer Family Fund
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Identifiers
- 991019167832304721
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- Collaboration types
- Domestic collaboration
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- Web of Science research areas
- Multidisciplinary Sciences