Journal article
Cefazolin versus cephalothin in β-lactamase-producing Staphylococcus aureus endocarditis in a rabbit experimental model
Journal of antimicrobial chemotherapy, v 9(5), pp 387-393
May 1982
PMID: 6980218
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effectiveness of cefazolin and cephalothin was compared in endocarditis in rabbits produced by two strains of beta-lactamase-producing Staphylococcus aureus. Cefazolin and cephalothin given intramuscularly for four days significantly protected against mortality and significantly reduced counts of Staph aureus in vegetations when compared with untreated controls. At four days the mortality rates with Strain 1 were: 94% in untreated controls, 20% in cefazolin treated rabbits and 55% in cephalothin treated animals. At four days the mortality rates with Strain 2 were: 95% in untreated rabbits, 43% in cefazolin treated rabbits and 50% in cephalothin treated animals. There were no significant differences in mortality or efficacy of treatment between cefazolin or cephalothin.
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Details
- Title
- Cefazolin versus cephalothin in β-lactamase-producing Staphylococcus aureus endocarditis in a rabbit experimental model
- Creators
- Jaime Carrizosa - Drexel UniversityWilliam D. Kobasa - Drexel UniversityRichard Snepar - Drexel UniversityKenneth M. Kaye - Drexel UniversityDonald Kaye - Drexel University
- Publication Details
- Journal of antimicrobial chemotherapy, v 9(5), pp 387-393
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1982NR38100009
- Scopus ID
- 2-s2.0-0020287528
- Other Identifier
- 991019184082004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Infectious Diseases
- Microbiology
- Pharmacology & Pharmacy