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Journal article
Cefoperazone treatment of experimental endocarditis
Antimicrobial agents and chemotherapy, v 19(5), pp 773-776
May 1981
PMID: 6457556
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Abstract
Cefoperazone (10 mg/kg) and cephalothin (20 mg/kg) administered intramuscularly every 6 h were both effective in reducing the number of Staphylococcus aureus cells in vegetations in rabbits with endocarditis. Cefoperazone produced higher peak concentrations and greater bactericidal activity in serum than did cephalothin. Cefoperazone (40 mg/kg) administered every 6 h was significantly more effective than cefamandole (40 mg/kg) administered every 6 h in reducing the number of Enterobacter aerogenes cells in vegetations. Although cefamandole produced higher peak concentrations in serum, the serum bactericidal activity was greater with cefoperazone. The half-lives in serum were 0.64 h for cefoperazone and 0.46 h for cephalothin and cefamandole.
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Details
- Title
- Cefoperazone treatment of experimental endocarditis
- Creators
- R A SneparJ CarrizosaW D KobasaD Kaye
- Publication Details
- Antimicrobial agents and chemotherapy, v 19(5), pp 773-776
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1981LS46300014
- Scopus ID
- 2-s2.0-0019829968
- Other Identifier
- 991019184042604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology
- Pharmacology & Pharmacy