Journal article
Ceftaroline for Central Nervous System Infections: Case Report of a Young Infant, and Scoping Review
The Pediatric infectious disease journal, v 43(7), pp 663-668
01 Jul 2024
PMID: 38451889
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Managing health care acquired and device-associated intracranial infections in young children can be challenging given adverse antibiotic side effects and difficulties in achieving adequate central nervous system (CNS) antibiotic concentrations. Ceftaroline is a cephalosporin with a favorable safety profile and activity against methicillin-resistant Staphylococci and several Gram-negative organisms. Published data on the use of ceftaroline for CNS infections in children and adults are limited. Methods: We describe a 2-month-old infant with ventriculo-subgaleal shunt-associated methicillin-resistant Staphylococcus epidermidis ventriculitis, which was successfully treated with ceftaroline, in addition to vancomycin and rifampin. We conducted a scoping review of English-language literature retrieved from PubMed, EMBASE and Web of Science that assessed the use of ceftaroline for CNS infections. Results: We identified 22 articles for inclusion in our review, which described 92 unique patients, of whom 2 were <21 years old. Ceftaroline was commonly used in conjunction with other antibiotics to treat infections caused by Staphylococcus aureus, coagulase-negative Staphylococci and Streptococcus pneumoniae. Most case reports described clinical success with ceftaroline, though small case series and cohort studies yielded mixed efficacy assessments. Adverse effects attributed to ceftaroline were rare and included reversible myelosuppression, eosinophilia, hepatotoxicity and nephrotoxicity. Pharmacokinetic/pharmacodynamic studies suggested similar CNS penetration through inflamed meninges as other beta lactam antibiotics. Conclusions: We identified a growing body of published evidence supporting the use of ceftaroline in combination with other agents for the treatment of CNS infections. In absence of clinical trials, additional real-world data are needed to define the efficacy and safety of ceftaroline for children and adults with CNS infections.
Metrics
Details
- Title
- Ceftaroline for Central Nervous System Infections: Case Report of a Young Infant, and Scoping Review
- Creators
- Haley Urbach - Yale New Haven HospitalNicole Sileo - Boston Children's HospitalSergio Lerma - College Station Medical CenterKevin Nguyen - St. Christopher's Hospital for ChildrenGiordano Sosa Soto - Boston Childrens Hosp, Dept Pediat, Div Infect Dis, Boston, MA USAMarisa Nielsen - Boston Medical CenterAmy Heiderich - Yale New Haven HospitalJames Holsapple - Boston Children's HospitalSharon Vuppula - Boston Medical CenterJeffrey I. Campbell - Boston Medical Center
- Publication Details
- The Pediatric infectious disease journal, v 43(7), pp 663-668
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physician Assistant
- Web of Science ID
- WOS:001252798000020
- Scopus ID
- 2-s2.0-85196766603
- Other Identifier
- 991022004764504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Pediatrics