Journal article
Cell Adhesion Molecules in Plasticity and Metastasis
Molecular cancer research, v 19(1)
01 Oct 2020
PMID: 33004622
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prior to metastasis, modern therapeutics and surgical intervention can provide a favorable long-term survival for patients diagnosed with many types of cancers. However, prognosis is poor for patients with metastasized disease. Melanoma is the deadliest form of skin cancer, yet i
n situ
and localized, thin melanomas can be biopsied with little to no post-surgical follow-up. However, metastatic melanoma patients require significant clinical involvement and have a 5-year survival of only 34–52%, largely dependent on the site of colonization. Melanoma metastasis is a multi-step process requiring dynamic changes in cell surface proteins regulating adhesiveness to the extracellular matrix (ECM), stroma, and other cancer cells in varied tumor microenvironments. Here we will highlight recent literature to underscore how cell adhesion molecules (CAMs) contribute to melanoma disease progression and metastasis.
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Details
- Title
- Cell Adhesion Molecules in Plasticity and Metastasis
- Creators
- Jessica A. Smart - Drexel UniversityJulia E. Oleksak - Drexel UniversityEdward J. Hartsough - Drexel University
- Publication Details
- Molecular cancer research, v 19(1)
- Publisher
- American Association for Cancer Research (AACR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000606538200003
- Scopus ID
- 2-s2.0-85100408419
- Other Identifier
- 991019168651404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Oncology