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Cell Biology: Resolving How DNA Is Damaged during 3D Migration
Journal article   Open access   Peer reviewed

Cell Biology: Resolving How DNA Is Damaged during 3D Migration

Ryan J. Petrie
Current biology, v 31(4), pp R209-R211
22 Feb 2021
PMID: 33621513
url
https://doi.org/10.1016/j.cub.2020.12.022View
Published, Version of Record (VoR)Open Access (Publisher-Specific) Open

Abstract

Biochemistry & Molecular Biology Biology Cell Biology Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Science & Technology
Cells migrating through confined spaces are subject to mechanical stresses that can deform the nucleus and even rupture the nuclear envelope. A new study reveals that nuclear deformation is sufficient to trigger double-strand breaks at sites of active DNA replication.

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Web of Science research areas
Biochemistry & Molecular Biology
Biology
Cell Biology
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