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Cell-Free DNA Screening for Trisomy 21 in Twin Pregnancy: A Large Multicenter Cohort Study
Journal article   Peer reviewed

Cell-Free DNA Screening for Trisomy 21 in Twin Pregnancy: A Large Multicenter Cohort Study

Lorraine Dugoff, Nathanael C. Koelper, Stephen T. Chasen, Melissa L. Russo, Ashley S. Roman, Meghana A. Limaye, Angela C. Ranzini, Caitlin M. Clifford, Joseph R. Biggio, Akila Subramaniam, …
Obstetrical & gynecological survey, v 79(4), pp 200-202
01 Apr 2024

Abstract

Life Sciences & Biomedicine Obstetrics & Gynecology Science & Technology
Cell-free DNA (cfDNA) screening is an effective way to identify trisomy 21 in singleton pregnancies and has been shown to have both a high detection rate and a low false-positive rate. For twin pregnancies, however, there are challenges relating to fetal fraction and the ability to obtain and distinguish fetal DNA.

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