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Cell-Free Identification of S-cerevisiae Strains by Analysis of Supernatant Using LC-MS
Journal article

Cell-Free Identification of S-cerevisiae Strains by Analysis of Supernatant Using LC-MS

Cathy Muste and Kevin G. Owens
Journal of the American Society for Mass Spectrometry, v 29(11), pp 2260-2267
01 Nov 2018
PMID: 30105741

Abstract

Biochemical Research Methods Biochemistry & Molecular Biology Chemistry Chemistry, Analytical Chemistry, Physical Life Sciences & Biomedicine Physical Sciences Science & Technology Spectroscopy Technology
Current literature shows a gap for methods which can identify yeast sub-species (strains or serovars) in samples where there are no viable cells remaining. Presented here is a technique for the analysis of yeast supernatant, including solid phase extraction, data-dependent acquisition liquid chromatography/mass spectrometry (LC-MS), and two chemometric methods to identify and classify yeast strains. Five strains of Saccharomyces cerevisiae were successfully identified in various stages of growth. In addition, peptide/protein identification was performed, without the need for additional data acquisition.

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Web of Science research areas
Biochemical Research Methods
Chemistry, Analytical
Chemistry, Physical
Spectroscopy
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