Journal article
Cell-bound complement activation products as lupus biomarkers: diagnosis, monitoring and stratification
Expert review of clinical immunology, v 13(12), pp 1133-1142
02 Dec 2017
PMID: 29025354
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Cell-bound complement activation products (CB-CAPs) were first reported in 2004, since which time multiple laboratories have demonstrated their value as biomarkers for diagnosis, monitoring, and stratification of patients with systemic lupus erythematosus.Areas covered: This review summarizes the highlights of these 14years of CB-CAPs discovery and validation, concluding with a view toward their future potential for precision medicine.Expert commentary: The practice of medicine is both art and science and each physician can be considered both artist and scientist with a variable blend of the two skill sets. There is arguably no disease that presents a greater challenge, nor a greater opportunity, for implementation of precision medicine, as does lupus. The physician who is presented with diagnosis and/or management of a patient suspected of having lupus will need to augment artistic skills with scientific guidance, and that science will be delivered in the form of biomarkers. Ultimately, we will likely have a lupus liquid biopsy' that will be 100% sensitive and 100% specific for a diagnosis of lupus. This will undoubtedly be a panel of biomarkers rather than an individual laboratory test. Such a liquid biopsy could transform lupus diagnosis to an entirely scientific process.
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Details
- Title
- Cell-bound complement activation products as lupus biomarkers: diagnosis, monitoring and stratification
- Creators
- Joseph M. Ahearn - Allegheny Health NetworkChau-Ching Liu - Allegheny Hlth Network, Lupus Ctr Excellence, Autoimmun Inst, Pittsburgh, PA USASusan Manzi - Allegheny Health Network
- Publication Details
- Expert review of clinical immunology, v 13(12), pp 1133-1142
- Publisher
- Taylor & Francis
- Number of pages
- 10
- Grant note
- 4100073189 / Pennsylvania Department of Health SAP
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000415972600003
- Scopus ID
- 2-s2.0-85034454245
- Other Identifier
- 991021933900504721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology