Journal article
Cell death mechanisms following traumatic brain injury
Brain pathology (Zurich, Switzerland), v 14(2), pp 215-222
Apr 2004
PMID: 15193035
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neuronal and glial cell death and traumatic axonal injury contribute to the overall pathology of traumatic brain injury (TBI) in both humans and animals. In both head-injured humans and following experimental brain injury, dying neural cells exhibit either an apoptotic or a necrotic morphology. Apoptotic and necrotic neurons have been identified within contusions in the acute post-traumatic period, and in regions remote from the site of impact in the days and weeks after trauma, while degenerating oligodendrocytes and astrocytes have been observed within injured white matter tracts. We review and compare the regional and temporal patterns of apoptotic and necrotic cell death following TBI and the possible mechanisms underlying trauma-induced cell death. While excitatory amino acids, increases in intracellular calcium and free radicals can all cause cells to undergo apoptosis, in vitro studies have determined that neural cells can undergo apoptosis via many other pathways. It is generally accepted that a shift in the balance between pro- and anti-apoptotic protein factors towards the expression of proteins that promote death may be one mechanism underlying apoptotic cell death. The effect of TBI on cellular expression of survival promoting-proteins such as Bcl-2, Bcl-xL, and extracellular signal-regulated kinases, and death-inducing proteins such as Bax, c-Jun N-terminal kinase, tumor-suppressor gene, p53, and the calpain and caspase families of proteases are reviewed. In light of pharmacologic strategies that have been devised to reduce the extent of apoptotic cell death in animal models of TBI, our review also considers whether apoptosis may serve a protective role in the injured brain. Together, these observations suggest that cell death mechanisms may be representative of a continuum between apoptotic and necrotic pathways.
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Details
- Title
- Cell death mechanisms following traumatic brain injury
- Creators
- Ramesh Raghupathi - Drexel University College of Medicine, 2900 Queen Ln, Philadelphia, PA, USA. ramesh.raghupathi@drexel.edu
- Publication Details
- Brain pathology (Zurich, Switzerland), v 14(2), pp 215-222
- Publisher
- Wiley; Switzerland
- Grant note
- NS41561 / NINDS NIH HHS NS08803 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000221410900013
- Scopus ID
- 2-s2.0-2442687858
- Other Identifier
- 991014878249504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pathology