Journal article
Cell delivery devices for cancer immunotherapy
JOURNAL OF CONTROLLED RELEASE, v 353, p875
Jan 2023
PMID: 36442617
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adoptive cell therapy (ACT) that leverages allogeneic or autologous immune cells holds vast promise in targeted cancer therapy. Despite the tremendous success of ACT in treating hematopoietic malignancies, its efficacy is limited in eradicating solid tumors via intravenous infusion of immune cells. With the extending technology of cancer immunotherapy, novel delivery strategies have been explored to improve the therapeutic potency of adoptively transferred cells for solid tumor treatment by innovating the administration route, maintaining the cell viability, and normalizing the tumor microenvironment. In this review, a variety of devices for cell delivery are summarized. Perspectives and challenges of cell delivery devices for cancer immunotherapy are also discussed.
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Details
- Title
- Cell delivery devices for cancer immunotherapy
- Publication Details
- JOURNAL OF CONTROLLED RELEASE, v 353, p875
- Publisher
- ELSEVIER; AMSTERDAM
- Grant note
- Acknowledgments Z.G. and H.L. would like to acknowledge the support from the Na-tional Key R&D Program of China (2021YFA0909900) , the National Natural Science Foundation of China (52173142) , and the grants from the Startup Package of Zhejiang University. H.C. thanks the support from Drexel University.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000910919900001
- Scopus ID
- 2-s2.0-85144370755
- Other Identifier
- 991021861275904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Pharmacology & Pharmacy