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Cell-material systems for anterior cruciate ligament regeneration
Journal article   Peer reviewed

Cell-material systems for anterior cruciate ligament regeneration

C Laurencin, M Attawia, E Botchwey, R Warren and E Attia
In vitro cellular & developmental biology. Animal, v 34(2), pp 90-92
01 Feb 1998
DOI: https://doi.org/10.1007/s11626-998-0088-8
PMID: 9542643
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

As an alternative to the currently used nondegradable polymers, investigators have begun to examine biodegradable materials that would provide immediate stabilization to the repaired ligament, but would also act as a scaffold for the ingrowth and/or replacement by host cells. The only completely degradable material currently reported under investigation for ACL repair is polyglycolic acid (PGA). Our laboratory has begun to examine the possible use of the copolymer PLAGA poly(D,L-lactide-co-glycolide) in conjunction with ligament cells as an alternative synthetic material in the use of soft tissue grafts. Candidate cell types to be used for soft tissue engineering purposes must be able to attach, grow, and maintain their phenotype on their newly seeded surfaces. The purpose of this study was to characterize the ability of various soft tissue cells to adhere to nondegradable and degradable PLAGA surfaces and to examine the morphology of these various cells during the process of attachment.

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8 citations in Web of Science
6 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Cell Biology
Developmental Biology
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