Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs
Nano research, v 11(10), pp 5573-5583
01 Oct 2018
PMID: 31656553
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The controlled release of therapeutics from microparticles or nanoparticles (NPs) has been well-studied. Incorporation of these particles inside biomaterial scaffolds is promising for tissue regeneration and immune modulation. However, these particles may induce inflammatory and foreign body responses to scaffold constructs, limiting their applications. Here we show that widely used poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) formed by double emulsion dramatically increased neutrophil infiltration and pro-inflammatory cytokines in alginate scaffolds 1 day after the subcutaneous injection of the scaffolds into mice. The coating of red blood cell (RBC) membranes on PLGA NPs completely eliminated these short-term inflammatory responses. For a longer term of 10 days, neither PLGA NPs nor RBC membrane-coated NPs exerted a significant effect on the infiltration of neutrophils or macrophages in alginate scaffolds, possibly due to the degradation and/or clearance of NPs by infiltrating cells. Despite the extensive exploration of cell membrane-coated NPs, our study is the first to investigate the effects of cell membrane coating on foreign body reaction to NPs. By harnessing the natural biocompatibility of cell membranes, our strategy of anti-inflammatory protection for scaffolds may be pivotal for many applications such as those relying on the recruitment of stem cells and/or progenitor cells to scaffolds.
Metrics
Details
- Title
- Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs
- Creators
- Zhiyuan Fan - Drexel UniversityPeter Y. Li - Drexel UniversityJunjie Deng - Chinese Academy of SciencesStephen C. Bady - Drexel UniversityHao Cheng - Drexel University
- Publication Details
- Nano research, v 11(10), pp 5573-5583
- Publisher
- Tsinghua Univ Press
- Number of pages
- 11
- Grant note
- R21AI133372 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Clinical & Translational Research Institute (CTRI) Drexel University R21AI133372 / National Institute of Allergy and Infectious Diseases of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000446423900032
- Scopus ID
- 2-s2.0-85046826431
- Other Identifier
- 991019169008604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied