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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons
Journal of comparative neurology (1911), v 525(9), pp 2202-2215
15 Jun 2017
PMID: 28266018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Local protein synthesis in mature axons may play a role in synaptic plasticity, axonal arborization, or functional diversity of the circuit. To gain insight into this question, we investigated the axonal localization of translational regulators and associated mRNAs in five parallel olfactory circuits, four in the main olfactory bulb and one in the accessory olfactory bulb. Axons in all four main olfactory bulb circuits exhibited axonal localization of Fragile X granules (FXGs), structures that comprise ribosomes, mRNA, and RNA binding proteins including Fragile X mental retardation protein (FMRP) and the related protein FXR2P. In contrast, FXGs were not seen in axons innervating the accessory olfactory bulb. Similarly, axons innervating the main olfactory bulb, but not the accessory olfactory bulb, contained the FXG-associated mRNA Omp (olfactory marker protein). This differential localization was not explained by circuit-dependent differences in expression of FXG components or Omp, suggesting that other factors must regulate their axonal transport. The specificity of this transport was highlighted by the absence from olfactory axons of the calmodulin transcript Calm1, which is highly expressed in peripheral olfactory neurons at levels equivalent to Omp. Regulation of axonal translation by FMRP may shape the structure and function of the axonal arbor in mature sensory neurons in the main olfactory system but not in the accessory olfactory system.
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Details
- Title
- Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons
- Creators
- Lulu I. T. Korsak - Drexel UniversityKatherine A. Shepard - Drexel UniversityMichael R. Akins - Department of BiologyDrexel UniversityPhiladelphia Pennsylvania19104
- Publication Details
- Journal of comparative neurology (1911), v 525(9), pp 2202-2215
- Publisher
- Wiley
- Number of pages
- 14
- Grant note
- R01HD052083 / NIH/NICHD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R01HD052083 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R00MH90237 / NIH/NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R00MH090237 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000400585200011
- Scopus ID
- 2-s2.0-85016168582
- Other Identifier
- 991019169617804721
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- Web of Science research areas
- Neurosciences
- Zoology