Journal article
Cellulose-Based Dual Graft Molecular Brushes as Potential Drug Nanocarriers: Stimulus-Responsive Micelles, Self-Assembled Phase Transition Behavior, and Tunable Crystalline Morphologies
Biomacromolecules, v 10(8), pp 2033-2042
01 Aug 2009
PMID: 19624155
Abstract
Well-defined cell ulose-based dual graft molecular brushes, composed of ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate)-graft-poly(epsilon-caprolactone) (EC-g-PDMAEMA-g-PCL), have been prepared by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Unlike other brush copolymers, the new molecular brushes show some unique physicochemical properties and multifunction due to their unique topological structures. These biocompatible copolymers self-assembled to micelles in aqueous solution. Upon pH change, the single micelles further assembled into micellar aggregates. As a result, the micelles in aqueous media could act as excellent drug nanocarriers for controlled drug release. The crystallinity and crystal morphology of the copolymers can be controlled to a certain extent by varying the length of the side chains, which may exert strong spacial restriction and, hence, affect the crystal structures.
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Details
- Title
- Cellulose-Based Dual Graft Molecular Brushes as Potential Drug Nanocarriers: Stimulus-Responsive Micelles, Self-Assembled Phase Transition Behavior, and Tunable Crystalline Morphologies
- Creators
- Qiang Yan - Tsinghua UniversityJinying Yuan - University of Tennessee at KnoxvilleFengbo Zhang - University of Tennessee at KnoxvilleXiaofeng Sui - University of Tennessee at KnoxvilleXuming Xie - University of Tennessee at KnoxvilleYingwu Yin - University of Tennessee at KnoxvilleShanfeng Wang - University of Tennessee at KnoxvilleYen Wei - University of Tennessee at Knoxville
- Publication Details
- Biomacromolecules, v 10(8), pp 2033-2042
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 10
- Grant note
- Li Ka-shing Foundation DE09848 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 20836004; 20574042 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2009CB930602 / National Basic Research Program; National Basic Research Program of China Chinese Ministry of Education; Ministry of Education, China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000268661400003
- Scopus ID
- 2-s2.0-68849098464
- Other Identifier
- 991019182773804721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Organic
- Polymer Science