Journal article
Central administration of p-octopamine to mice: assessment of antinociception
European journal of pharmacology, v 169(2), pp 317-320
10 Oct 1989
PMID: 2509222
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Administration of p-octopamine by intracerebroventricular (i.c.v.) or intrathecal (i.t.) routes, but not orally, produced antinociception in the acetylcholine-induced abdominal constriction test (ED
50 = 24.8 and 3.6
μg, respectively). Likewise, i.c.v. and i.t., but not peripheral (up to 200 mg/kg s.c.), administration increased latency in the 48°C hot-plate test (ED
50 = 11.5
μg i.c.v. and 0.2
μg i.t.). These actions were relatively long-lasting and not blocked by naloxone. Antinociception following i.c.v. administration was abolished in reserpinized mice or by pretreatment with i.t. phentolamine (2 μg). These results suggest a moderate antinociceptive action of p-octopamine involving non-opioid. reserpine-sensitive, central pathways.
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Details
- Title
- Central administration of p-octopamine to mice: assessment of antinociception
- Creators
- Robert B. Raffa - JanssenJoanne R. Mathiasen - JanssenTamara L. Goode - Janssen
- Publication Details
- European journal of pharmacology, v 169(2), pp 317-320
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1989AW62700016
- Scopus ID
- 2-s2.0-0024436933
- Other Identifier
- 991021900192404721
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- Web of Science research areas
- Pharmacology & Pharmacy