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Journal article
Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS
Proceedings of the National Academy of Sciences - PNAS, v 104(24), pp 10146-10151
12 Jun 2007
PMID: 17548817
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Histamine (HA), a biogenic amine with a broad spectrum of activities in both physiological and pathological settings, plays a key regulatory role in experimental allergic encephalomyelitis, the autoimmune model of multiple sclerosis. HA exerts its effect through four G protein-coupled receptors designated HA receptor H1, H2, H3, and H4. We report here that, compared with wild-type animals, mice with a disrupted HA H3 receptor (H3RKO), the expression of which is normally confined to cells of the nervous system, develop more severe disease and neuroinflammation. We show that this effect is associated with dysregulation of blood-brain barrier permeability and increased expression of MIP-2, IP-10, and CXCR3 by peripheral T cells. Our data suggest that pharmacological targeting of the H3R may be useful in preventing the development and formation of new lesions in multiple sclerosis, thereby significantly limiting the progression of the disease.
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Details
- Title
- Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS
- Creators
- Cory Teuscher - University of VermontMeena Subramanian - University of VermontRajkumar Noubade - University of VermontJian Feng Gao - University of VermontHalina Offner - Oregon Health and Science University HospitalJames F Zachary - University of Illinois at Urbana-ChampaignElizabeth P Blankenhorn - Drexel University
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 104(24), pp 10146-10151
- Publisher
- PNAS; United States
- Number of pages
- 6
- Grant note
- AI 058052 / NIAID NIH HHS R01 AI041747 / NIAID NIH HHS P01 AI045666 / NIAID NIH HHS AI 045666 / NIAID NIH HHS NS 036526 / NINDS NIH HHS R01 NS036526 / NINDS NIH HHS AI 041747 / NIAID NIH HHS R01 AI058052 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000247363000042
- Scopus ID
- 2-s2.0-34547142877
- Other Identifier
- 991014878217704721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology