Logo image
Back
Ceramic-based multisite electrode arrays for chronic single-neuron recording
Journal article

Ceramic-based multisite electrode arrays for chronic single-neuron recording

Karen A Moxon, Steve C Leiser, Greg A Gerhardt, Kenneth A Barbee and John K Chapin
IEEE transactions on biomedical engineering, v 51(4), pp 647-656
Apr 2004
DOI: https://doi.org/10.1109/TBME.2003.821037
PMID: 15072219

Abstract

Microelectrodes Neurons - pathology Monitoring, Ambulatory - instrumentation Reproducibility of Results Monitoring, Ambulatory - methods Rats, Long-Evans Rats Male Neurons - cytology Electrodes, Implanted Ceramics Equipment Design Nerve Net - physiology Somatosensory Cortex - pathology Action Potentials - physiology Animals Sensitivity and Specificity Somatosensory Cortex - cytology Equipment Failure Analysis
A method is described for the manufacture of a microelectrode array for chronic, multichannel, single neuron recording. The ceramic-based, multisite electrode array has four recording sites patterned onto a ceramic shaft the size of a single typical microwire electrode. The sites and connecting wires are applied to the ceramic substrate using a reverse photolithographic procedure. Recording sites (22 x 80 microm) are separated by 200 microm along the shaft. A layer of alumina insulation is applied over the whole array (exclusive of recording sites) by ion-beam assisted deposition. These arrays were capable of recording single neuron activity from each of their recording sites for at least three weeks during chronic implantation in the somatosensory cortex of rats, and several sites had recordings that lasted for more than 8 weeks. The vertical arrangement of the recording sites on these electrodes is ideal for simultaneously recording across the different layers of brain areas such as the cerebral cortex and hippocampus in chronic preparations.

Metrics

9 Record Views
92 citations in Web of Science
117 citations in Scopus

Details

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Engineering, Biomedical
Logo image