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Cerastes cerastes (Egyptian Sand Viper) venom induced platelet aggregation as compared to other agonists
Journal article   Peer reviewed

Cerastes cerastes (Egyptian Sand Viper) venom induced platelet aggregation as compared to other agonists

Gerald Soslau, M.Farid El-Asmar and Janet Parker
Biochemical and biophysical research communications, v 150(3), pp 909-916
15 Feb 1988
DOI: https://doi.org/10.1016/0006-291X(88)90715-2
PMID: 2829899
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

The Egyptian Sand Viper (Cerastes cerastes) crude venom and subfractions were, for the first time, shown to induce platelet aggregation with agonist activities present in two subfractions. The combined activities of the crude venom components behaved in a unique fashion as compared to the platelet agonists, ADP, collagen and thrombin. The action of the venom was inhibited by conditions that increased cAMP, partially required the formation of thromboxane A2 and was inhibited by the serine protease inhibitor PMSF while being only partially sensitive to leupeptin or soybean trypsin inhibitor. One of the fractionated venom agonists strongly induced serotonin release while the other venom agonist essentially did not. Further characterization of the Cerastes cerastes venom components should broaden our knowledge of the pathology of snake venoms, platelet aggregation and their potential therapeutic value.

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23 citations in Web of Science
25 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Biochemistry & Molecular Biology
Biophysics
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