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Cerebral atherosclerosis in selected chronic disease states
Journal article   Peer reviewed

Cerebral atherosclerosis in selected chronic disease states

A.C. Klassen, R.B. Loewenson and J.A. Resch
Atherosclerosis, v 18(2), pp 321-336
1973
DOI: https://doi.org/10.1016/0021-9150(73)90108-1
PMID: 4742855

Abstract

Atherosclerotic heart disease Cancer Cerebral atherosclerosis Cerebral vascular disease Chronic disease Chronic pulmonary disease Chronic renal disease Diabetes mellitus Malignant neoplastic disease Peptic ulcer disease
The severity of atherosclerotic involvement of the intracranial cerebral arteries was assessed at autopsy in 3942 adult subjects. The values obtained in groups of subjects at various ages were correlated with the presence or absence of selected chronic disease states. The presence of clinical or pathological evidence of cerebral vascular disease, atherosclerotic heart disease, diabetes mellitus, and, to a lesser degree, chronic renal disease was associated with a relative increase in the severity of cerebral atherosclerosis. In contrast, cerebral atherosclerosis was apparently less severe in groups of subjects with malignant neoplastic disease and peptic ulcer disease. In males with cirrhosis or alcoholism, there was a possible tendency toward less severe cerebral atherosclerosis.

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