Journal article
Cerebrovascular Events in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
Arthritis care & research (2010), v 70(10), pp 1478-1487
Oct 2018
PMID: 29316357
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE).
A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient ischemia, 3) chronic multifocal ischemia, 4) subarachnoid/intracranial hemorrhage, and 5) sinus thrombosis. Global disease activity (Systemic Lupus Erythematosus Disease [SLE] Activity Index 2000), damage scores (SLE International Collaborating Clinics/American College of Rheumatology Damage Index), and Short Form 36 (SF-36) scores were collected. Time to event, linear and logistic regressions, and multistate models were used as appropriate.
CerVEs were the fourth most frequent NP event: 82 of 1,826 patients had 109 events; of these events, 103 were attributed to SLE, and 44 were identified at the time of enrollment. The predominant events were stroke (60 of 109 patients) and transient ischemia (28 of 109 patients). CerVEs were associated with other NP events attributed to SLE, non-SLE-attributed NP events, African ancestry (at US SLICC sites), and increased organ damage scores. Lupus anticoagulant increased the risk of first stroke and sinus thrombosis and transient ischemic attack. Physician assessment indicated resolution or improvement in the majority of patients, but patients reported sustained reduction in SF-36 summary and subscale scores following a CerVE.
CerVEs, the fourth most frequent NP event in SLE, are usually attributable to lupus. In contrast to good physician-reported outcomes, patients reported a sustained reduction in health-related quality of life following a CerVE.
Metrics
Details
- Title
- Cerebrovascular Events in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
- Creators
- John G Hanly - Queen Elizabeth II Health Sciences CentreQiuju Li - MRC Biostatistics UnitLi Su - University of CambridgeMurray B Urowitz - Toronto Western HospitalCaroline Gordon - University of BirminghamSang-Cheol Bae - Hanyang University Seoul HospitalJuanita Romero-Diaz - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránJorge Sanchez-Guerrero - Toronto Western HospitalSasha Bernatsky - McGill UniversityAnn E Clarke - University of CalgaryDaniel J Wallace - Cedars-Sinai Medical CenterDavid A Isenberg - University College LondonAnisur Rahman - University College LondonJoan T Merrill - Oklahoma Medical Research FoundationPaul Fortin - Centre hospitalier de l'Université LavalDafna D Gladman - Toronto Western HospitalIan N Bruce - Manchester Academic Health Science CentreMichelle Petri - Johns Hopkins MedicineEllen M Ginzler - SUNY Downstate Health Sciences UniversityM A Dooley - University of North Carolina at Chapel HillKristjan Steinsson - Reykjavík UniversityRosalind Ramsey-Goldman - Northwestern UniversityAsad A Zoma - Hairmyres HospitalSusan Manzi - Allegheny Health NetworkOla Nived - Lund UniversityAndreas Jonsen - Lund UniversityMunther A Khamashta - St Thomas' HospitalGraciela S Alarcón - University of Alabama at BirminghamWinn Chatham - University of Alabama at BirminghamRonald F van Vollenhoven - Karolinska InstitutetCynthia Aranow - Feinstein Institute for Medical ResearchMeggan Mackay - Feinstein Institute for Medical ResearchGuillermo Ruiz-Irastorza - Hospital de CrucesManuel Ramos-Casals - Consorci Institut D'Investigacions Biomediques August Pi I SunyerS Sam Lim - Emory UniversityMurat Inanc - Istanbul UniversityKenneth C Kalunian - University of California San DiegoSoren Jacobsen - Copenhagen University HospitalChristine A Peschken - University of ManitobaDiane L Kamen - Medical University of South CarolinaAnca Askanase - New York UniversityChris Theriault - Queen Elizabeth II Health Sciences CentreVernon Farewell - University of Cambridge
- Publication Details
- Arthritis care & research (2010), v 70(10), pp 1478-1487
- Publisher
- Wiley
- Grant note
- 5-UL-1TR001422-02 / NCATS NIH HHS M01 RR000046 / NCRR NIH HHS UL1 TR000150 / NCATS NIH HHS Department of Health U105261167 / Medical Research Council Wellcome Trust MC_U105261167 / Medical Research Council UL1 RR025741 / NCRR NIH HHS P60 AR048098 / NIAMS NIH HHS P60 AR064464 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000445724000008
- Scopus ID
- 2-s2.0-85052841350
- Other Identifier
- 991021933908104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology