Journal article
Ceruletide acts in the abdomen, not in the brain, to produce satiety
Peptides (New York, N.Y. : 1980), v 5(6), pp 1149-1157
Nov 1984
PMID: 6099563
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ceruletide (caerulein), a decapeptide extracted from the skin of the frog,
Hyla caerulea, is very similar in structure to the C-terminal octapeptide of cholecystokinin (CCK-8). Although ceruletide and CCK-8 act through similar or identical receptors to produce the same visceral effects, previous studies in the rat suggested that peripherally administered ceruletide acted directly on the ventromedial hypothalamic (VMH) area to decrease food intake, but peripherally administered CCK-8 acted at a vagally innervated abdominal site to decrease food intake. Since it is unprecedented for these two peptides to produce the same effect by acting at different sites, we investigated the site of action of ceruletide's satiety effect in the rat and compared it to the site of action of CCK-8. The major results were: (1) intraperitoneal administration of ceruletide and CCK-8 inhibited food intake, but intraventricular administration did not; (2) the satiety effect of ceruletide and CCK-8 was not changed by bilateral lesions of the VMH; and (3) the satiety effect of ceruletide and CCK-8 was abolished or markedly reduced by bilateral abdominal vagotomy. We conclude that ceruletide acts at the same vagally innervated abdominal site to produce satiety as CCK-8 does and that neither peptide acts directly on the VMH area.
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Details
- Title
- Ceruletide acts in the abdomen, not in the brain, to produce satiety
- Creators
- G.P. Smith - Cornell UniversityC. Jerome - Cornell UniversityP. Kulkosky - Cornell UniversityK.J. Simansky - Cornell University
- Publication Details
- Peptides (New York, N.Y. : 1980), v 5(6), pp 1149-1157
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:A1984ABV9400017
- Scopus ID
- 2-s2.0-0021676916
- Other Identifier
- 991021842660304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Pharmacology & Pharmacy