Journal article
Cesium-131 prostate brachytherapy: A single institutional long-term experience
Brachytherapy, v 19(3), pp 298-304
May 2020
PMID: 32249178
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To report on the PSA outcomes in men undergoing prostate seed implant (PSI) with Cesium-131 at a single institution.
All patients who underwent prostate brachytherapy with Cesium-131 (
Cs) at our institution and had the potential for at least 24 months of follow up were included in this study. Results are reported for the by NCCN risk group (low, low/high-intermediate, and high), as well as by treatment received (monotherapy, combination external beam radiation + PSI, or trimodal therapy with androgen deprivation). The Phoenix definition (absolute nadir plus 2 ng/mL) was used to define biochemical freedom from disease (BFD).
Eight hundred and six men have undergone prostate brachytherapy with Cesium-131 at our institution, and 669 men were included in analysis. Median follow up was 60.0 months (range: 0-144 months). According to NCCN risk categories, 29.9% were low-, 55.6% intermediate-, and 14.5% high-risk. Using the Phoenix criteria, 5/10-year BFD was 97.1/95.3% for patients in the low-risk category, 94.0/90.1% for patients in the intermediate-risk category, and 86.2/56.6% for patients in the high-risk category. PSA ≤0.2 ng/dL at 4 years was predictive of 10 year biochemical control: 96.3% vs 70.4%, p < 0.001.
The present study demonstrates that prostate brachytherapy with
Cs achieves excellent long-term biochemical control.
Metrics
Details
- Title
- Cesium-131 prostate brachytherapy: A single institutional long-term experience
- Creators
- Ronald M Benoit - University of Pittsburgh School of MedicineZachary D Horne - Allegheny Health NetworkChristopher J Houser - University of PittsburghRyan P Smith - University of PittsburghSushil Beriwal - University of Pittsburgh
- Publication Details
- Brachytherapy, v 19(3), pp 298-304
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000530101100004
- Scopus ID
- 2-s2.0-85082759555
- Other Identifier
- 991021897369004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging