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Journal article
Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment
Molecules (Basel, Switzerland), Vol.24(7), 1219
28 Mar 2019
PMID: 30925755
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We describe progress and obstacles in the development of novel peptide-hydrogel therapeutics for unmet medical needs in ischemia treatment, focusing on the development and translation of therapies specifically in peripheral artery disease (PAD). Ischemia is a potentially life-threatening complication in PAD, which affects a significant percentage of the elderly population. While studies on inducing angiogenesis to treat PAD were started two decades ago, early results from animal models as well as clinical trials have not yet been translated into clinical practice. We examine some of the challenges encountered during such translation. We further note the need for sustained angiogenic effect involving whole growth factor, gene therapy and synthetic growth factor strategies. Finally, we discuss the need for tissue depots for de novo formation of microvasculature. These scaffolds can act as templates for neovasculature development to improve circulation and healing at the preferred anatomical location.
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Details
- Title
- Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment
- Creators
- Karel Petrak - NangioTx Inc., Newark, NJ 07102, USA. petrak@nangiotx.comRavi Vissapragada - Flinders Medical CentreSiyu Shi - Stanford MedicineZain Siddiqui - New Jersey Institute of TechnologyKa Kyung Kim - New Jersey Institute of TechnologyBiplab Sarkar - New Jersey Institute of TechnologyVivek A Kumar - New Jersey Institute of Technology
- Publication Details
- Molecules (Basel, Switzerland), Vol.24(7), 1219
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991021956615304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary