Journal article
Change in depressive symptoms during the prodromal phase of Alzheimer disease
Archives of general psychiatry, v 65(4), pp 439-446
01 Apr 2008
PMID: 18391132
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prospective studies have established an association between depressive symptoms and risk of dementia, but how depressive symptoms change during the evolution of dementia is uncertain. To test the hypothesis that depressive symptoms increase during the prodromal phase of Alzheimer disease (AD). Prospective cohort study. For up to 13 years, 917 older Catholic nuns, priests, and monks without dementia at study onset completed annual clinical evaluations that included administration of the 10-item Center for Epidemiologic Studies Depression Scale and clinical classification of mild cognitive impairment and AD. Change in depressive symptoms reported on the Center for Epidemiologic Studies Depression Scale. At baseline, participants reported a mean (SD) of 1.0 (1.5) depressive symptoms. Those who developed AD (n = 190) showed no increase in depressive symptoms before the diagnosis was made, and this finding was not modified by age, sex, education, memory complaints, vascular burden, or personality. There was no systematic change in depressive symptoms after the AD diagnosis, although symptoms tended to decrease in women relative to men and in those with a higher premorbid level of openness and a lower premorbid level of agreeableness. Among those without cognitive impairment at baseline, depressive symptoms did not increase in those who subsequently developed mild cognitive impairment. We found no evidence of an increase in depressive symptoms during the prodromal phase of AD.
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Details
- Title
- Change in depressive symptoms during the prodromal phase of Alzheimer disease
- Creators
- Robert Wilson - Rush University Medical CenterSteven ArnoldTodd BeckJulia BieniasDavid Bennett
- Publication Details
- Archives of general psychiatry, v 65(4), pp 439-446
- Publisher
- American Medical Association
- Number of pages
- 8
- Grant note
- R01 AG15819; R01 AG015819; P30 AG10161; R01 AG024871 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01AG024871 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry; Family (Community and Preventive) Medicine
- Web of Science ID
- WOS:000254752000008
- Scopus ID
- 2-s2.0-42049104112
- Other Identifier
- 991020785738304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry