Journal article
Changes in Aorta Alpha1-Adrenoceptor Number and Affinity during One Year of Streptozotocin-Induced Diabetes in Rats
Pharmacology, v 74(1)
Apr 2005
PMID: 15640611
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
α1-Adrenoceptor function and density in isolated thoracic aorta were measured during the course of streptozotocin-induced diabetes in rats. Diabetes was induced by a single tail vein injection of streptozotocin (60 mg/kg) and was verified by four measures (blood glucose level, increase in food intake, increase in water intake, and characteristic weight changes). Diabetes produced a significant increase in isolated aorta sensitivity to α1-adrenoceptor activation, manifested as a significant (p < 0.05) decrease in theA50 value for phenylephrine and an increase in the A50 (control)/A50 (diabetic) ratio (1.2, 1.7, and 2.0, respectively) with increasing length of diabetes (4, 12 and 52 weeks). There was a large and biphasic change in receptor density (Bmax), without a significant change (p > 0.05) in either agonist (phenylephrine) or antagonist (prazosin) affinities (KA and pA2 values, respectively). These results suggest compensatory mechanisms in receptor number and abnormalities in 2nd messenger transduction and can help direct efforts for improving antihypertensive or other pharmacological therapy for diabetic patients.
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Details
- Title
- Changes in Aorta Alpha1-Adrenoceptor Number and Affinity during One Year of Streptozotocin-Induced Diabetes in Rats
- Creators
- Robert J Schulingkamp - Temple UniversityVincent AloyoRonald J TallaridaRobert B Raffa
- Publication Details
- Pharmacology, v 74(1)
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000228257800004
- Scopus ID
- 2-s2.0-17844380801
- Other Identifier
- 991019167577704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy