Journal article
Changes in Blood Profile from Steady State in Patients with Sickle Cell Anemia Admitted for Vaso-occlusive Crisis and Acute Chest Syndrome
Advances in hematology, v 2020, pp 1-5
2020
PMID: 32908517
Abstract
Close to half of all patients with sickle cell disease (SCD) will have at least one episode of acute chest syndrome (ACS) during their lifetime. Multiple cells and molecules involved with the inflammatory cascade play a role in the development of ACS. We found that patients with SCD who developed ACS as a complication of a vaso-occlusive crisis (VOC) had a significant increase in leukocytes and decrease in platelets from their steady state when compared with a separate admission for VOC without ACS development. No significant change from steady state hemoglobin or reticulocyte count was noted between the two admissions. These results indicate that trending laboratory markers may be useful to predict patients at risk for ACS development.
Metrics
20 Record Views
1 citations in Scopus
Details
- Title
- Changes in Blood Profile from Steady State in Patients with Sickle Cell Anemia Admitted for Vaso-occlusive Crisis and Acute Chest Syndrome
- Creators
- Timothy Klouda - St. Christopher's Hospital for ChildrenDeepti Raybagkar - St. Christopher's Hospital for ChildrenBruce Bernstein - St. Christopher's Hospital for ChildrenNataly Apollonsky - St. Christopher's Hospital for Children
- Publication Details
- Advances in hematology, v 2020, pp 1-5
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Scopus ID
- 2-s2.0-85091405251
- Other Identifier
- 991021448189404721