Journal article
Changes in optical properties of tissue during acute wound healing in an animal model
Journal of Biomedical Optics, v 13(4), pp 044005-0440011
26 Aug 2008
PMID: 19021333
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Changes of optical properties of wound tissue in hairless rats were quantified by diffuse photon density wave methodology at near-infrared frequencies. The diffusion equation for semi-infinite media was used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain device. There was an increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared with the nonwounded sites. The changes correlated with the healing stage of the wound. The data obtained were supported by immunohistochemical analysis of wound tissue. These results verified now by two independent animal studies could suggest a noninvasive method to detect the progress of wound healing.
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Details
- Title
- Changes in optical properties of tissue during acute wound healing in an animal model
- Creators
- Elisabeth S Papazoglou - Drexel University, School of Biomedical Engineering, Philadelphia, PennsylvaniaMichael S Weingarten - Drexel University College of Medicine, Department of Surgery, Philadelphia, PennsylvaniaLeonid Zubkov - Drexel University, School of Biomedical Engineering, Philadelphia, PennsylvaniaMichael Neidrauer - Drexel University, School of Biomedical Engineering, Philadelphia, PennsylvaniaLinda Zhu - Drexel University, School of Biomedical Engineering, Philadelphia, PennsylvaniaSom Tyagi - Drexel University, Department of Physics, Philadelphia, PennsylvaniaKambiz Pourrezaei - Drexel University, School of Biomedical Engineering, Philadelphia, Pennsylvania
- Publication Details
- Journal of Biomedical Optics, v 13(4), pp 044005-0440011
- Publisher
- Society of Photo-Optical Instrumentation Engineers (SPIE)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Physics; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000259901000029
- Scopus ID
- 2-s2.0-58149378429
- Other Identifier
- 991014877681304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Optics
- Radiology, Nuclear Medicine & Medical Imaging