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Journal article
Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
Frontiers in aging neuroscience, v 8, pp 208-208
31 Aug 2016
PMID: 27630559
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammatory profiles. Astrocyte senescence has been implicated in neurodegenerative disease, and to better understand senescence-associated changes in astrocytes, we investigated changes in their transcriptome using RNA sequencing. Senescence was induced in human fetal astrocytes by transient oxidative stress. Brain-expressed genes, including those involved in neuronal development and differentiation, were downregulated in senescent astrocytes. Remarkably, several genes indicative of astrocytic responses to injury were also downregulated, including glial fibrillary acidic protein and genes involved in the processing and presentation of antigens by major histocompatibility complex class II proteins, while pro-inflammatory genes were upregulated. Overall, our findings suggest that senescence-related changes in the function of astrocytes may impact the pathogenesis of age-related brain disorders.
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Details
- Title
- Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
- Creators
- Elizabeth P. Crowe - Drexel UniversityFerit Tuzer - Drexel UniversityBrian D. Gregory - University of PennsylvaniaGreg Donahue - University of PennsylvaniaSager J. Gosai - University of PennsylvaniaJustin Cohen - Drexel UniversityYuk Y. Leung - University of PennsylvaniaEmre Yetkin - Drexel UniversityRaffaella Nativio - University of PennsylvaniaLi-San Wang - University of PennsylvaniaChristian Sell - Drexel UniversityNancy M. Bonini - University of PennsylvaniaShelley L. Berger - University of PennsylvaniaF. Brad Johnson - University of PennsylvaniaClaudio Torres - Drexel University
- Publication Details
- Frontiers in aging neuroscience, v 8, pp 208-208
- Publisher
- Frontiers Media S.A
- Grant note
- RO1NS078283 / National Institute of Neurological Disorders and Stroke R21AG046943 / National Institute on Aging F30AG043307 / National Institute on Aging
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Neurobiology and Anatomy; Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000382354300002
- Scopus ID
- 2-s2.0-84990045997
- Other Identifier
- 991019168238104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Neurosciences