Journal article
Changes occur in the ability to promote axonal regeneration as the post-injury period increases
Neuroreport, v 8(3), pp 751-755
10 Feb 1997
PMID: 9106760
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
THIS study tested whether adult rat brain stem neurons could respond to growth or trophic factors provided after an extended post-injury period. The number of neurons that regenerated their axon into a peripheral nerve graft following exposure to ciliary neurotrophic factor (CNTF) 8 weeks after a cervical lesion was comparable to the number regenerating after exposure to CNTF 4 weeks after injury. In contrast, there was a significant decrease of 50% in the number of regenerating neurons following exposure to basic fibroblast growth factor (bFGF) 8 weeks after injury compared with the number regenerating after treatment with bFGF 4 weeks after injury. These results indicate that some factors are effective promoters of regeneration only if provided within a defined post-injury period.
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Details
- Title
- Changes occur in the ability to promote axonal regeneration as the post-injury period increases
- Creators
- J Houle - University of Arkansas for Medical SciencesJian Ye
- Publication Details
- Neuroreport, v 8(3), pp 751-755
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997WQ00600036
- Scopus ID
- 2-s2.0-0030963539
- Other Identifier
- 991020545124004721
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- Web of Science research areas
- Neurosciences