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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Characteristics of highly cross-linked polyethylene wear debris in vivo
Journal of biomedical materials research. Part B, Applied biomaterials, v 101(3), pp 467-475
22 Feb 2013
PMID: 23436587
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Despite the widespread implementation of highly cross-linked polyethylene (HXLPE) liners to reduce the clinical incidence of osteolysis, it is not known if the improved wear resistance will outweigh the inflammatory potential of HXLPE wear debris generated
in vivo
. Thus, we asked: What are the differences in size, shape, number, and biological activity of polyethylene wear particles obtained from primary total hip arthroplasty revision surgery of conventional polyethylene (CPE) versus remelted or annealed HXLPE liners? Pseudocapsular tissue samples were collected from revision surgery of CPE and HXLPE (annealed and remelted) liners, and digested using nitric acid. The isolated polyethylene wear particles were evaluated using scanning electron microscopy. Tissues from both HXLPE cohorts contained an increased percentage of submicron particles compared to the CPE cohort. However, the total number of particles was lower for both HXLPE cohorts, as a result there was no significant difference in the volume fraction distribution and specific biological activity (SBA; the relative biological activity per unit volume) between cohorts. In contrast, based on the decreased size and number of HXLPE wear debris there was a significant decrease in total particle volume (mm
3
/g of tissue). Accordingly, when the SBA was normalized by total particle volume (mm
3
/gm tissue) or by component wear volume rate (mm
3
/year), functional biological activity of the HXLPE wear debris was significantly decreased compared to the CPE cohort. Indications for this study are that the osteolytic potential of wear debris generated by HXLPE liners
in vivo
is significantly reduced by improvements in polyethylene wear resistance.
Metrics
Details
- Title
- Characteristics of highly cross-linked polyethylene wear debris in vivo
- Creators
- Ryan M. Baxter - Drexel UniversityDaniel W. MacDonald - Drexel UniversitySteven M. Kurtz - Exponent (United States)Marla J. Steinbeck - Drexel University
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, v 101(3), pp 467-475
- Publisher
- Wiley
- Grant note
- R01 AR047904 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000316573600011
- Scopus ID
- 2-s2.0-84875374467
- Other Identifier
- 991019168605904721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials