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Journal article
Characterization of G10P[11] Rotaviruses Causing Acute Gastroenteritis in Neonates and Infants in Vellore, India
Journal of clinical microbiology, v 42(6), pp 2541-2547
01 Jun 2004
PMID: 15184432
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Abstract
Rotavirus G10P[11] strains, which are commonly found in cattle, have frequently been associated with asymptomatic neonatal infections in India. We report the finding of G10P[11] strains associated with severe disease in neonates in Vellore, southern India. Rotavirus strains from 43 fecal samples collected from neonates with or without gastrointestinal symptoms between 1999 and 2000 were genotyped by reverse transcription-PCR. Forty-one neonates (95%) were infected with G10P[11] rotavirus strains, and 63% of the infections were in children who had gastrointestinal symptoms, including acute watery diarrhea. G10P[11] strains were also seen infecting older children with dehydrating gastroenteritis in Vellore. Characterization of the genes encoding VP7, VP4, VP6, and NSP4 of these strains revealed high sequence homology with the corresponding genes of the asymptomatic neonatal strain I321, which in turn is very closely related to bovine G10P[11] strains circulating in India. No significant differences were seen in the sequences obtained from strains infecting symptomatic neonates or children and asymptomatic neonates.
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Details
- Title
- Characterization of G10P[11] Rotaviruses Causing Acute Gastroenteritis in Neonates and Infants in Vellore, India
- Creators
- Miren Iturriza Gómara - Christian Medical CollegeGagandeep Kang - Christian Medical CollegeAjit Mammen - Christian Medical CollegeAtanu Kumar Jana - Institute of Child HealthMary Abraham - Christian Medical CollegeUlrich Desselberger - Laboratoire de Virologie Moléculaire et StructuraleDavid Brown - Christian Medical CollegeJim Gray - Christian Medical College
- Publication Details
- Journal of clinical microbiology, v 42(6), pp 2541-2547
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000222015800028
- Scopus ID
- 2-s2.0-2942555310
- Other Identifier
- 991021838152104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Microbiology