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Journal article
Characterization of In Vitro Chlamydia muridarum Persistence and Utilization in an In Vivo Mouse Model of Chlamydia Vaccine
American journal of reproductive immunology (1989), v 69(5), pp 475-485
01 May 2013
PMID: 23414449
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Problem Chlamydia trachomatis genital tract infections are easily treated with antibiotics; however, the majority of infections are asymptomatic and therefore untreated, highlighting the need for a vaccine. Because most infections are asymptomatic, vaccination could potentially be administered to individuals who may have an acute infection at that time. In such individuals, the effect of vaccination on the existing infection is unknown; however, one potential outcome could be the development of a persistent infection. In vitro chlamydial persistence has been well characterized in various strains; however, there have been no reported studies in C.muridarum. Method of Study We performed ultrastructural characterization and transcriptome analysis of selected genes. We then used the transcriptional profiles of the selected genes to examine whether intranasal immunization of mice during an active genital infection would induce persistence in the upper reproductive tract of female mice. Results and Conclusions We found that persistence developed in the oviducts of mice as a result of immunization. This is a significant finding, not only because it is the first time that C.muridarum persistence has been characterized in vitro, but also due to the fact that there is a minimal characterization of in vivo persistence of any chlamydial species. This highlights the importance of the timing of vaccination in individuals.
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Details
- Title
- Characterization of In Vitro Chlamydia muridarum Persistence and Utilization in an In Vivo Mouse Model of Chlamydia Vaccine
- Creators
- Alison J. Carey - Queensland University of TechnologyWilhelmina M. Huston - Queensland University of TechnologyKelly A. Cunningham - Queensland University of TechnologyLouise M. Hafner - Queensland University of TechnologyPeter Timms - Queensland University of TechnologyKenneth W. Beagley - Queensland University of Technology
- Publication Details
- American journal of reproductive immunology (1989), v 69(5), pp 475-485
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- 497260 / Australian National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Drexel University
- Web of Science ID
- WOS:000317666100006
- Scopus ID
- 2-s2.0-84876323376
- Other Identifier
- 991020100213904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Reproductive Biology