Journal article
Characterization of a putative nuclear receptor from Onchocerca volvulus
Molecular and biochemical parasitology, v 104(2), pp 259-269
1999
PMID: 10593180
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Steroids and retinoids are important regulators of development in invertebrates and vertebrates. The central mediators of action of these compounds are their cognate receptors, which together form a family of proteins known as the nuclear receptor family. Previous studies have demonstrated that the genome of
Onchocerca volvulus encodes at least three members of the nuclear receptor family. Here, the characterization of one member of this family from
O. volvulus, designated OvNR-2, is described. OvNR-2 was found to be most similar to a number of vertebrate retinoic acid receptors and to the
Drosophila melanogaster EiP78c protein. Modeling studies suggest that OvNR-2 forms a boot shaped ligand-binding cavity of a shape and size that can bind steroids. Expression of the mRNA corresponding to OvNR-2 is tightly regulated in adult parasites, appearing only in the extended intrauterine microfilariae. The protein derived from expression of the OvNR-2 cDNA in a bacterial system is recognized by serum antibodies in a majority of individuals infected with
O. volvulus.
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Details
- Title
- Characterization of a putative nuclear receptor from Onchocerca volvulus
- Creators
- Thomas R Unnasch - University of Alabama at BirminghamJanette Bradley - University of SalfordJeremy Beauchamp - University of GlasgowRocky Tuan - Allegheny CollegeMalcolm W Kennedy - University of GlasgowJennifer A Bradley - Nurse Practitioner Master of Science in Nursing (MSN)
- Publication Details
- Molecular and biochemical parasitology, v 104(2), pp 259-269
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nurse Practitioner Master of Science in Nursing (MSN)
- Web of Science ID
- WOS:000083972100010
- Scopus ID
- 2-s2.0-0032742693
- Other Identifier
- 991019168844704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Parasitology