Journal article
Characterization of age-related changes in natural killer cells during primary influenza infection in mice
Mechanisms of ageing and development, v 129(4), pp 223-230
2008
PMID: 18304606
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The current investigation examined the importance of natural killer (NK) cells during the innate immune response to primary influenza infection in young and aged mice. Young (6–8 weeks) and aged (22 months) C57BL/6 mice were infected intranasally with influenza A virus, and NK cell-mediated cytotoxicity was determined in lung and spleen during the first 4 days of infection. Aged mice demonstrated both a decrease in influenza-inducible NK activity and a reduction in the percentage and number of NK1.1+ cells in response to primary influenza infection, relative to young mice. In order to further establish a role for NK cells in controlling influenza infection, young mice were depleted of NK cells
in vivo by injecting rabbit anit-NK1.1 antibody 2 days and 1 day prior to influenza infection. Young mice depleted of NK cells exhibited increased weight loss and lung virus titers during the course of infection, compared to young mice infected with influenza virus. These data indicate that NK cell function is impaired in response to primary influenza infection in aged mice. More importantly, these results underscore the essential role of NK cells in controlling virus titers in lung during the early course of influenza infection, regardless of age.
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Details
- Title
- Characterization of age-related changes in natural killer cells during primary influenza infection in mice
- Creators
- Shoko Nogusa - Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, United StatesBarry W Ritz - Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, United StatesSadik H Kassim - Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, United StatesStephen R Jennings - Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, United StatesElizabeth M Gardner - Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, United States
- Publication Details
- Mechanisms of ageing and development, v 129(4), pp 223-230
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000254769600007
- Scopus ID
- 2-s2.0-39749203402
- Other Identifier
- 991014877924304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology