Journal article
Characterization of antibody responses to annual influenza vaccination over four years in a healthy elderly population
Vaccine, v 19(32), pp 4610-4617
2001
PMID: 11535308
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effects of yearly influenza immunization on the level of antibody responses were assessed in 92 healthy elderly subjects immunized over four contiguous years (1993–1996) with a trivalent influenza vaccine that included A/Texas annually. Anti-A/Texas antibodies increased significantly and similarly post-vaccination each year, but returned to comparable baseline levels annually. Percentages of subjects with anti-A/Texas titers ≥40 post-vaccination were comparable over four years. Importantly, post-vaccination titers ≥40 to A/Texas in 1993–1994 predicted anti-A/Texas titers ≥40 in subsequent years. Thirty percent of individuals produced four-fold rises to any vaccine component the first year it was included in the vaccine, however, this percentage decreased to about 10% after subsequent vaccination with the same component. This study clearly supports the concept that annual immunization with the same influenza vaccine component over multiple years does not significantly decrease antibody titers in a healthy elderly population.
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Details
- Title
- Characterization of antibody responses to annual influenza vaccination over four years in a healthy elderly population
- Creators
- Elizabeth M Gardner - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USAErica D Bernstein - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USASandra Dran - Department of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USAGary Munk - Department of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USAPeter Gross - Department of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USAElias Abrutyn - Department of Medicine, MCP Hahnemann University Schools of Medicine and Public Health, 2900 Queen Lane, Philadelphia, PA 19129, USADonna M Murasko - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
- Publication Details
- Vaccine, v 19(32), pp 4610-4617
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000171035500005
- Scopus ID
- 2-s2.0-0035860574
- Other Identifier
- 991014878014704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental