Journal article
Characterization of self-cleaving RNA sequences on the genome and antigenome of human hepatitis delta virus
Journal of virology, v 62(12), pp 4439-4444
Dec 1988
PMID: 3184270
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recently we reported that in vitro RNA transcripts complementary to the genome of hepatitis delta virus (HDV) contain a unique site at which self-cleavage can occur. Subsequent studies showed that a similar self-cleavage site was present on in vitro RNA transcripts of genomic HDV RNA. The same self-cleavage reactions were also found to occur on HDV RNAs from the livers of infected chimpanzees. Using the in vitro RNA it was also possible to determine that the minimum length of contiguous sequence needed for self-cleavage of genomic RNA was 30 bases 5' and 74 bases 3' of the cleavage site. This sequence was not compatible with the "hammerhead" structure hypothesized to be important in the self-cleavage reactions of other RNAs.
Metrics
Details
- Title
- Characterization of self-cleaving RNA sequences on the genome and antigenome of human hepatitis delta virus
- Creators
- M Y Kuo - Fox Chase Cancer CenterL Sharmeen - Fox Chase Cancer CenterG Dinter-Gottlieb - Fox Chase Cancer CenterJ Taylor - Fox Chase Cancer Center
- Publication Details
- Journal of virology, v 62(12), pp 4439-4444
- Publisher
- American Society for Microbiology (ASM)
- Grant note
- CA-22651 / NCI NIH HHS CA-06927 / NCI NIH HHS RR-05539 / NCRR NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:A1988Q990900001
- Scopus ID
- 2-s2.0-0024209351
- Other Identifier
- 991019183926904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology