Journal article
Characterization of two plasma membrane proteins abundant in rat brain
Brain research, v 415(2), pp 375-379
1987
PMID: 3607506
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Abstract
Plasma membranes were isolated from rat brain cortices and their proteins characterized by two-dimensional electrophoresis. Approximately 500 polypeptides with relative molecular weights (mol. wt.) between 20 kDa and 120 kDa and isoelectric points (pI) between 4.2 and 8.5 were visualized by silver staining. Two proteins, MP
1 and MP
2, comprised about 5% each of the total by mass. Their mol. wts. were 56 kDa and 43 kDa, and their pIs were 4.2 and 4.3, respectively. The two proteins were present in membranes of cultured granule neurons and cortical astrocytes and absent in liver and kidney. They were both substrates for phosphorylation by protein kinase C. MP
2 is similar, if not identical, to a major phosphoprotein in growth cones, pp46 (also termed GAP-43, B-50, F1).
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Details
- Title
- Characterization of two plasma membrane proteins abundant in rat brain
- Creators
- Hans Werner Steisslinger - National Institute of Neurological Disorders and StrokeVincent J. Aloyo - Drexel UniversityLjubisˇa Vitković - National Institute of Neurological Disorders and Stroke
- Publication Details
- Brain research, v 415(2), pp 375-379
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1987J232200023
- Scopus ID
- 2-s2.0-0023183784
- Other Identifier
- 991019184283904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences